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A New Treatment for Canine Idiopathic Epilepsy: Pexion

A New Treatment for Canine Idiopathic Epilepsy: Pexion

We recently wrote about canine idiopathic epilepsy, a form of epilepsy where the cause remains unknown. Today we are looking at a new treatment; Pexion.

The severity of epilepsy can vary greatly between individual sufferers. Some dogs may experience a single, isolated seizure, whilst other can experience multiple seizures every week.

Recently Boehringer Ingelheim has announced their latest product for the treatment of canine epilepsy, Pexion® (Pexion) an alternative to the traditional phenobarbital or potassium bromide treatments given to epileptic dogs.

Are you using Pexion?

If you’re dog has been prescribed Pexion, let us know how your dog is getting on in the comments below. Join the discussion on how other dog owners are getting on with Pexion and keep the community updated with your progress. 

What Is Pexion?

Unlike other treatments for canine epilepsy, Pexion contains the active ingredient Imepitoin. Imepitoin acts in a similar manner to previous anti-epileptic medicines, potassium bromide and phenobarbital, in that it works to suppress electrical activity in the brain.

Imepitoin partially activates GABA receptors, which are responsible for reducing electrical activity between nerve cells. This partial activation of the GABA receptors is believed to reduce electrical activity and help prevent seizures. Specifically, Imepitoin also has a weak blocking effect on calcium channels that allow electrical signals to be propagated along nerve cells.

See here for more information about Pexion 

Does Pexion Work?

A study conducted on Pexion during its development compared it to the traditional anti-epileptic medicine phenobarbital. A 20 week study of 226 dogs taking the medications found Pexion matched phenobarbital in efficacy, reducing the occurence of seizures by around 50%. 1

Is Pexion a Better Alternative?

The Pexion study showed that it had an effectiveness equivalent to phenobarbital, however, Pexion may be considered a better alternative as it has less severe side effects.

Unlike phenobarbital, Pexion does not pose a hepatotoxicity risk (liver toxicity). This means the regular testing required to ensure that a dog’s liver remains healthy is not needed whilst being given Pexion.

Treating the Epileptic Dog

It is commonly cited that around 0.5 to 5% of dogs suffer from some form of epilepsy, the severity varying between breeds and individuals. In dogs where seizures occur infrequently  owners may consider not using any medication at all, avoiding the side effects associated with anti-epileptic medications.

In dogs where seizures occur more freqently, such as once a month or more, treatment should be considered.

The introduction of Pexion gives owners and vets a greater choice when it comes to treatment, but does not replace phenobarbital and potassium bromide.

Owners should consult their vet and explore all the possibilities when dealing with an epileptic dog.

Seizure Types That Require Immediate Veterinary Assistance

Cluster seizures – When multiple seizures occur in one 24 hour period
Status epilepticus – A persistent epileptic state that lasts for longer than 5 minutes

For more information about epilepsy, such as the causes, what to do during a seizure and more, see this article.

Disclaimer: This article was written as a response to the release of Pexion and as a follow up to a previous article concerning idiopathic epilepsy. I am not affiliated with the product (Pexion) or the manufacturer (Boehringer). 

Image Credit: Onkel_wart

About James Watts

BSc Bioveterinary Science. Editor of PetSci. When I'm not writing, learning, discussing, or reading about animals, you know it's the weekend!


  1. My dachshund started having seizures shortly before his second birthday about three weeks apart. After all the tests came back normal the vet put him on Pexion. Unfortunately the seizures increased in frequency despite going to the maximum dose. So I have to say that this medication has not worked for my dog. He is now on Epiphen and so far he has not had any more fits. Worried about side effects though.

    • Susan, You don’t say what dose of Epiphen your Dachsie is on, nor whether your Dachsie is mini or standard. My Shani is just over 9lbs, a mini longhaired. She was 7 years old in May and has been epileptic since birth. she is now on 15mgs pheno BID but also Gabapentin and potassium bromide. But she is not my first epi and I chose pheno because of its proven success. I also have a dog with liver disease (her uncle) so know how to help Shani deal with any problems caused by her drugs. Side effect initially is the ataxia, which should disapear in two or three weeks. She should have pheno level tested at 2 weeks and periodically thereafter. She can be given milk thistle to help the liver deal with any drugs. You could put her on Epitaur, which is for epieltpci dogs and recommended by Richard Allport, the homeopathic vet. Here is a link to it:

      • Hi Jean thank you for your reply. My dachsie is around 6.25 kg smooth. His takes 12.5mg pheno twice a day. The seizures occur less frequently now than when he was on Pexion, about three weeks apart. I asked the vet about milk thistle but he didn’t feel it was necessary at this stage (?) Otherwise he is fine with good energy levels. I will definitely look into giving the Epitaur. Is this an alternative to milk thistle?

        • Hello Susan.

          Luckily your dog is on a very small dose of epiphen..I imagine he is a standard if he is 6.25kg. Shani is just over 4kgs and has just had her pheno reduced to 15mg. But she is also on the other meds.

          My old vet back in England knew nothing about milk thistle, many vets aren’t familiar with things unless they are drugs, which milk thistle isn’t. The point of milk thistle is to try to prevent damage to the liver and not wait until there are problems. Epitaur is a support for the liver, but does not contain milk thistle. This link tells you what’s in the capsules and what effect they have Shani always had milk thistle separately until her liver enzymes were raised and now she has Doxion, which contains SAMe and milk thistle as well as other nutrients to aid the liver.

          There is a great epilepsy group that you could join online It’s mostly American but there are quite a lot of other nationalities too and the best one I’ve ever discovered. And I’ve had epi dogs since the 80s. If your boy is still having seizure with not a lot of time between you might need to increase the pheno slightly.

  2. Hi Wendy
    If your dog has not had other medication for fits/epilepsy, it might be worth changing the drug…
    Talk to your vet and see what he/she says, also show them this website.
    I was not happy about the dose my dog was having as there was no change at all in the frequency of fits and as it happened he had a couple 12 hours apart, which may have been due to Pexion.
    My vet read from the veterinary drug handbook about Pexion and said in some cases the fits will INCREASE on Pexion, which is why he took my dog off of the drug.

    • Did your vet reduce the dose gradually, Kay, or just stop it? Some say it is safe to stop at any time and others recommend it is done gradually.

    • Thank you for the advice Kay, Daisy has been on 1200mg of Pexion for 13 days now, so far she has not had a fit but she has never gone more than 2 weeks without one, so I am expecting one very soon. Iam not gong to increase her dose any higher if she has another fit even though the vet will probably recommend it. I am going to insist that she tries another medication even though the vet says that other medications makes them drowsy and they have no quality of life!
      I was talking o someone yesterday who’s dog as epilepsy but the epilepsy is controlled by diet. He said that it is something about the protein in their diet, do you anything about his Kay?

      • Hi Wendy, I do wish you luck finding the right medication. I noticed that someone had mentioned protein in the diet. When Bronte first began having fits I got in touch with the Canine Epilepsy Support Group who advised me to change her food to the lowest protein food available and rotate it (Chappie, Butcher’s etc.) I also used Bach’s Rescue Remedy and gave her a supplement called Taurine. Bronte has never had any meds other than Pexion and I agreed to it because I was told it was a wonder drug with no side effects. I am not convinced and thinking of taking her off it. Link to Epilepsy Support is and my contact is Anne Morley at Good luck xx

      • What a worry for you Diane that your collie is having fits as he is so young. Please do try cutting out all processed dog food, that includes tins of food. I am now giving my dogs who are young, raw mashed vegetables twice a day(that includes ALL VEGETABLES AND MOST FRUIT ) raw bones every other day for their teeth and raw heart, liver, chicken legs and wings and any other raw steak I can get cheaply from the butcher. I am convinced it is todays dry processed dog food that predisposes to the increase of fits in our beloved animals. I have said so often on this blog that fits were never mentioned in dogs fifty years ago and indeed I had never heard of dogs having fits until my own beautiful border collie started having them a year ago. Now I have lost her and I do not want to lose my young collie who is just one. Please just give it a try anyway. There is so much on the net now about BARF feeding for pets. Its very easy and much cheaper than those bags of nuts that are all sprayed with some ghastly fat spray to make them more edible.

        All the best,


  3. Hi Val
    He decreased gradually, five days with one morning and night and five days with a half morning and night…
    He has not replaced it with anything though, no fits as of yet…. he used to have one fit approx. a fortnight. So since last Thursday no tablets of anything. Fingers crossed.

  4. Hi my border collie started fitting just after his first birthday which was a total shock for us as a family. Took him in overnight as it was a Sunday they took good care of him and put him on phenobarbital . Started him on a small dose but now has 60mg twise a day has cluster fits every three weeks. Spent more time in hospital as the fits were not controlled , now also has pexion 100mg twise a day. He went three weeks without any fits and then to the pattern had another cluster fits that lasted all day don’t know where to go from here

  5. I am sorry to hear about your dog Diane, I think it is trial and error with all drugs, drugs all have pros and cons. Has your vet mentioned potassium bromide? I think that you can use that with phenobarbital if your dog tolerates it. I will NOT put Ernie on phenobarbital – he came off all drugs 9 days ago and no fits yet….. his last fit was 12th July so he was due to have a fit a fortnight after that, so far so good. if I have to I might start on potassium bromide.
    Also if your dog is just one isn’t that unusual for it to be idiopathic epilepsy? I thought the fits normally start around the age of 2 for that? Has the vet talked about any other causes? Suggested an MRI scan?
    I think the raw diet my work for some. Ernie has a good dry dog food with no grains at all, but I would consider the raw if he has fits and they are not controlled by other drugs.
    Sorry Wendy I didn’t see the question you asked about protein. I haven’t heard of a link to protein. I will look at the link that Val b posted.

    • Hi Kay I’ve investigated that border collies if they have idiopathic epilepsy starts after there first birthday which is what happened to brody. He has been seen by the vrcc veterinary referrals cancer and critical care centre they have ruled out brain tumours or anything else other than what they have said he has. Thank you for your advice .

  6. I forgot to post this.

    people may have seen it but I was interested in this on that link….

    Pexion 100 mg and 400 mg tablets for dogs

    Contra-indications, warnings, etc

    Do not use in case of hypersensitivity to the active substance or to any of the excipients. Do not use in dogs with severely impaired hepatic function, severe renal or severe cardiovascular disorders.

    The pharmacological response to imepitoin may vary and efficacy may not be complete. Nevertheless imepitoin is considered to be a suitable treatment option in some dogs because of its safety profile. On treatment, some dogs will be free of seizures, in other dogs a reduction of the number of seizures will be observed, whilst others may be non-responders.
    In non-responders, an increase in seizure frequency may be observed.
    Should seizures not be adequately controlled, further diagnostic measures and other antiepileptic treatment should be considered.

    The benefit/risk assessment for the individual dog should take into account the details in the product literature.

    The efficacy of the veterinary medicinal product in dogs with status epilepticus and cluster seizures has not been investigated. Therefore, imepitoin should not be used as primary treatment in dogs with cluster seizures and status epilepticus. Transition to other types of antiepileptic therapy should be done gradually and with appropriate clinical supervision.

    No loss of anticonvulsant efficacy (tolerance development) during continuous treatment of 4 weeks was observed in experimental studies lasting 4 weeks.

  7. My bichon is 5 years old and recently started to have fits. He is now on Pexion 2 in the morning followed by 2 at night. They are defintly not working. Sometimes he is having four fits in two days. Then he may go 5 days without a fit.
    I feel that I can’t leave him alone in case he hurts himself.
    Please can you give me any advice?

    • Hi Niki
      I am sorry to hear about your dog.
      I can only advise talking to your vet about your experiences.
      If you think that your dog has become worse or is fitting more then perhaps ask if you could try another drug.
      You know your dog best, how he is acting on the tablets and whether he is worse or if there is no change.
      I hope things get better for you soon

  8. Well my Daisy managed to go 4 weeks and 1 day without a fit until Monday of this week where she had 8 fits in 24 hours. I rushed her to the vets because she was in a very bad way (hallucinating, stressed and not with it) now 3 days on she is still a bit nervous, has only just remembered who we are but the dog I know seems to be gone. I am hoping that it is a result of so many fits in such a short period of time and she will get back to normal. My vet has now agreed with me after 2 months of telling them that Pexion is not working! She is booked in for an MRI next week because my vet suspects that she has a brain tumour. I am hoping and praying that that is not the case and she is the way she is now because of so many fits in such a short period of time. Has anyone else experienced this with their dog?

    • Hi Wendy – yes, our own dog had the exact pattern that you describe. He was diagnosed with epilepsy in February and was seizure free for three months on Pexion. He had another small fit, but then had eight siezures close together a few weeks ago and was exactly as you describe. We rushed him to the vet and it took three days for him to settle again. He was staggering, crashing into things, falling over, etc but he did recover and was back to being bouncy, happy and enjoying life after three days. It is an ongoing process for us at the moment as all blood tests for thyroid problems etc are proving inconclusive and we are changing the medication. Fingers crossed here for you and dog.

      • Hi Sal, have you changed your dogs medication yet? I have had a long discussion today about changing Daisy’s medication. I have to start her tomorrow on epiphen and she is also going to give me kappra to keep in the house to give to her if she has cluster fits again. Daisy is still not 100% after nearly a week, she seems to have forgotten certain words and is not interested in the slightest about going for a walk whereas before the 8 fits she loved her walks. She is going on Thursday to vets just so that she can check her over, fingers crossed her problems at the minute are due to so many fits in such a short time, please let me know how you get on with the medication Sal, all the best of luck

  9. Hi daisy my border collie brody has been on pexion and phenobarbital for two months and totally agree with you that it does not seen to stop the fits. he had many fits all through the day and night which was Tuesday the 2nd of sept he still is not 100% now we are waiting to hear from our vet as they do not really know what to do with him he is only 17mouths x

  10. Every three to four weeks he has cluster fits x

    • Dear Dianne,
      My dog Izzy was put on pexion when it had been out a few months, she had her first fit at a year old and continued to have 3 or 4 fits every 3 weeks. My vet put her on epiphen initially and when that didn’t stop the siezures added Lebromide, she still continued to have seizures regular as clockwork. I took her down to Cambridge University to their Animal Hospital as Anne Van Haesenbrauk a top neurologist had studied canine epilepsy and I was so desperate to help my beautiful dog. They did a brain scan and drew fluid from the spinal column and found nothing so she was diagnosed with Idiopathic Epilepsy. We continued on the medication adjusting the doses but she still had regular fits until she had a really bad episode and we found that the bromide was not suitable and we nearly lost her t pancreatitus. It was at this time that pexion came out and I weaned Izzy off the Epiphen whilst starting with pexion. I had also changed her diet to BARF using mainly chicken inc bones and found other natural ways like Bachs rescue oil, skullcap & valerian tablets. Nothing worked and when she was just on the pexion we thought we’d cracked it as she went for 6 weeks nearly without a fit, and then she started having them weekly-every saturday and she had in excess of 30 seizures over the weekend, she spent the last 2 weekends at my vets heavily sedated with valium. After the first weekend I stopped the Pexion as suggested in the notes and wish I had put “The Valium Protocol” in place before stopping the Pexion. I believe to this day that if I had reduced the dose slowly it may have made things better for her as the withdrawal brought on the clusters that took her life. My vets could only sedate her to stop the fits temporarily and as soon as they brought her round the clusters continued- after so many (every 3/4 minutes) her temperature had risen to high and we don’t think she’d have been able to function like that, so the decision was made by us and my vet to put her down- she was only 3 and a half. If you look up the canine epilepsy guardian angels website, they have loads of information on there, most of the people have had an epileptic animal and are full of ideas that you may find helpful.
      I wish you all the luck in the world and hope you find something that works so you don’t have to go through the pain of losing your dog. My postings on this forum are exactly a year ago, from May/June to 2nd September hen Izzy was pts and no longer suffering. May the angels be with you.
      Love Amanda x

  11. Thank you Amanda I will defo look on their web site thank you for sharing your story x

    • I am so sorry that so many people are not having any luck with Pexion.

      Murphy is a 25kg labradoodle and has been on Pexion for just over a year now. He started out having 400mg twice a day and we’ve gradually had to increase this to 600mg twice a day, but ‘touch wood’ its working brilliantly for him. He doesn’t cluster fit, but as soon as he has a fit I administer rectal diazepam. There is no pattern at all to his fits, he has only had five so far this year, and hasn’t had once since mid-June.

      I really hope that other people on here do find something that works for their dog, its an awful, heart breaking disease.

  12. My 14 year old Bichon who has never had a fit all her life had several in one weekend a couple of weeks ago. We went to bed as usual one Friday night, only for me to be startled awake about 3 hours later by her distressed barking. She seemed to be having some sort of fit. She’d wet the bed and the episode lasted roughly about a minute. Of course being startled awake and seeing her like that scared the living daylights out of me. I phoned the vet who was on call that night and she agreed that it sounded like some sort of seizure and to take her to the surgery the following morning. After a very sleepless night and 7 and a half hours later she had another one- This one didn’t seem to last as long as the first one, but otherwise was exactly the same with the distressed barking, wetting herself etc. I phoned the vet again to tell her that she’d had a second episode then took her to the surgery and hour or so later after she’d come round a bit. The vet immediately started her on Pexion 100mg half a tablet twice daily because of her age and being quite frail. On examination she also had a bit of a temperature- nothing too drastic- but gave her a long acting antibiotic injection just to be safe. Saturday afternoon she perked up alot and seemed to be back to her usual self. Saturday night however was really bad. I gave her the second dose of Pexion later that evening and maybe an hour or so later I noticed she wasn’t herself again. Very heavy breathing and I started to get a bit worried again and never left her side. Low and behold nearly 14 hours after the second seizure she had that morning she had her third. I was alot calmer this time for my dogs sake rather than mine but was still very upset to see her like this when she’d perked up so much just hours earlier. Again the episode was exactly the same as the other two (distressed barking, wetting herself and it lasted about the same as the second one). Then about hour and a half later just as we’d settled down for bed she had a fourth. Although I remained calm for her I was now VERY concerned. Her breathing became very rapid. I should have phoned the vet but didn’t because I knew she would have got even more distressed if I had to take her to the surgery again and she needed to be admitted overnight. Instead I had her right next to me all night keeping contact as much as possible. The very rapid breathing went on nearly all night and she wet herself several times but there didn’t seem to be any seizure that I was aware of. Early the following morning (about 7.30am) she had another one and again it was the same as the others. That was just over a week ago (it will be 2 weeks next Sunday, 23rd Sept) and she hasn’t had anything since. I’m assuming it’s the Pexion that has stopped her from having anymore of these seizures and I will be continuing to give them to her. The main reason I have come to this page was to see if there were any side effects to this drug. My dog was drinking a little more than usual before starting Pexion, but now it’s increased even more. It’s not just her increased thirst either, but her appetite now as well. I don’t really want to stop giving this drug to her as I’d much rather her have increased thirst and hunger over seizures any day. Any feedback will be greatly appreciated. Before I go the vet seemed to think that these seizures were more likely to be age related rather than epilepsy as she’s an old girl now.

    • Hi Tracy,
      Glad to hear that your dog is better on Pexion – I can confirm that increased hunger and thirst are two of the side effects of Pexion. I hope she will continue to do well xx

      • Thank you so much for replying. Angel has gone what would have been 2 weeks today with no fit, but just now as I am writing this she is in my arms recovering from a very slight one. I just hope she’ll perk up later on now. It is now nearly 6am and I am up at this unearthly hour on a Sunday because Angel woke me up at about 4.30am desperate for a drink. I am kind of relieved to know that increased hunger and thirst are side effects, but Angels thirst seems a bit extreme. It’s not the first time she has woke me up during the early hours crying for a drink. And when I take her downstairs for one she is drinking solid for a good couple of minutes sometimes longer. She has had a load of blood tests done fairly recently- kidney function being one of them- and apart from that one being slightly abnormal everything was fine. I’m not sure though if they checked her glucose levels. I will be getting back in touch with the vet on Monday to check. I don’t really want her to be poked and prodded too much now that she is old and fragile as a trip to the vet really distresses her.
        The fit she had this morning now was different to the others. She wet herself the same as before and she also had that rapid like breathing. But there was no barking this time though. I don’t actually think I’d have noticed that she’d had one if I wasn’t awake and she was in her bed by my feet. Thank you again for replying. What do you think about her extreme thirst though. As I said in my first post, before she was put on Pexion her thirst had increased which I put down to the hot weather, but it has now sky rocketed.

        • Hi Tracy,
          I wouldn’t class my dog’s thirst or hunger are extreme, but both are certainly noticeably increased since being on Pexion. Also, her fits have changed on the drug – they have been fewer but of longer duration and much more pronounced. And instead of having the usual warning beforehand, she has simply collapsed in front of me and on another occasion discharged her anal glands, though she has not yet been incontinent in a fit. My vet agrees with me that anything regularly exceeding 4/5 minutes is dangerous, and Bronte’s last fit was of 10 minutes’ duration. It is for this reason that she is coming off the Pexion – so far been on half the dose for a month, now on a quarter for another week and then she will come off it altogether. The vet confirmed that it is not necessary to wean them off it gradually, but she wanted to see what happened, if anything, on a reduced dose. So far, the result is positive. My vet admits to being disappointed with Pexion’s performance after all the hype.
          It sounds as if you may need to visit your vet as you mention; would it be an idea to phone first and find out if they tested Angel’s blood glucose last time? Kidney health can be a concern in old age but it sounds as if that was reasonable at the time of her last test.
          I know how you feel; it is devastating to see them suffering at any time. I hope you can get some answers and that you and Angel can find some peace and rest. Try to stay positive – that won’t be easy – but if you can be as calm and relaxed as possible it will help you both.
          Good luck and lots of love xx

          • Thank you for replying again Val. I am sorry to hear about your dogs fit lasting 10 minutes. That must have been truly horrifying to see. I’ve noticed that most of the replies about Pexion on here have been negative. I seem to be the only one to say that it has worked. My baby is tiny so maybe it only works on little dogs :) I don’t know what breed Bronte is with you, but my Angel is a very small Bichon- so small she’s still mistaken for a puppy, even at 14. Anyway, since my last reply Angel hasn’t been very well. I haven’t taken her to the vet yet as I didn’t want to get her even more upset. I’m gonna phone this morning though to see if her vet is on duty. I agree that Pexion has changed the way she has a fit. Sadly though I think there is alot more going on with Angel. I am preparing myself for the worst. I am also thinking she is having fits in her sleep as the past 2 mornings in a row now she has also soiled her bed as well as wet it. All in all, I refuse to let her suffer. The vet told me when I first took her the following morning after having 2 fits in a matter of hours that she was very frail and I think I’d rather make that god awful decision for her to go peacefully rather than her have a big fit or something and lose her that way.
            I really hope all works well for Bronte and thank you again for getting back to me about the thirst and hunger. It’s good to know and I will also inform my vet as when I first asked her she didn’t know. Love from us both xx

  13. I have 2 boxers reg and Harvey who are nearly 3 years old , last year reg started to have seizers , after lots of care and attention from my vet the fits were under control and reg was put onto Phenobarbital , he had one fit every 3-4 months ( I could cope with that ) but because stay on Phenobarbital can damage his liver my vet wanted to wean him off Phenobarbital and start using pexion , with days of starting pexion he was fitting he was having 10 to 15 fits a day , after seeing my emergency vet they stopped the pexion straight away , they said to carry on with the Phenobarbital and after a day of being off pexion he stopped having the fits , the vets are now going to try a differnt medication but I will never have him on pexion again . He is back to being very playful and loving .

    • Try adding a few drops of milk thistle tincture to his diet (in water) it helps protect dogs liver just like it does for humans.
      Obviously check with your vet first.
      Amanda x

      • Thank you for that Amdanda I vet had never mentioned this , reg is due back next week for his bloods so I will emotion it ty very much :) x

  14. I would not recommend Pexion to anyone. I have lost my little baby girl Princess who was only 5.5 years old to Epilepsy a few months after my Vet recommended to change her medication from Phenobarbital (Ephiphen) to Pexion. The Vet`s reason for the change was that the blood tests seemed difficult to take from my small chihuahua and apparently Pexion had no damaging side effects. Says who exactly. After a few weeks being on Pexion my baby started acting funny she would snap at me and be very insecure but i was told it was a normal side effect as we were wheening her off epiphen to go on pexion. However a couple months has passed and she was still very snappy and she would be confused at some times, i felt her eye sight got worst as well, however we were happy as she had no seizure for several months since she was on Pexion whilst she was on epiphen she would have one or two every couple of months. However came the 5th month on pexion my dog was very unsettled this whole month and been depressed twice we actually had to take her to the vet as we didn’t know why she was so down. She would not eat, play want to be stroked or want to go for walks which was very unusual as she was such an active little dog. The doctor couldn’t really give us an explanation just told us to watch her as she may be due on a seizure. 2 weeks on and she had not one but 3 clusters seizure during the night one after the other each being longer than the previous ones she has managed to recover after each until the fourth one (by when she was at the emergency vet) where i had no control or knowledge of what was happening. The vet put her on Vallium drip as well as done a quick blood test on her but she was so weak and worn down due to these cluster of seizers (which she has never ever in her entire life she had before) that by the time the 5th seizure came her heart would give up after the last one the vet performed CPR and managed to bring her back for a brief time but slowly my little angel faded away as it was just all too much for her. I am so very devastated for the loss of my baby girl and i wish i have never switched from epiphen to Pexion as according to this vet Pexion has not helped my baby girl`s seizures but made it worst instead of her having one seizure each month pexion stopped her having one but instead it collated it them and she ended up having even more dangerous cluster seizures. Pexion has killed my dog and i couldn’t do anything to stop this. Please if you love your dog do not go on pexion without doing the much needed research pexion had the same effect on my other dogs. your dog`s idiopathic seizure could easily turn into cluster of seizure on Pexion as pexion is not a certified drug for all seizures and is definatelty not able to control cluster seizures.Unfortunately it is too late for my dog but it is hopefully not too late for yours.

    • I am so sorry to read what you and your lovely dog went through. I also was advised to change as Pexion is better for the liver. My dog also started having cluster seizures and I got a second opinion and took her off the Pexion back on to pheno plus KBr. We trust in our vets to do the best but in my case I wonder if my vet made any money for each dog they got on the new drug. My dog is fine now thankfully and I’m so sorry you were too late.

  15. Eva, your story has made me cry, I am so sorry for your loss. My dog Daisy has followed almost the same pattern as your dog from being on Pexion. We are now in the process of weaning he off of Pexion onto epiphen. She has been on epiphen for nearly 2 weeks now, unfortunately she is still on Pexion because the vet says that she has to follow a protocol and wean her off slowly. She is on the maximum dose of Pexion (1400mg plus 120mg of epiphen twice a day) She has got to have a blood test at the end of this week to make sure that the level of epiphen is high enough to start reducing the Pexion. The combination of the 2 drugs are making her very drowsy and sometimes she falls over or walks into things. I am hoping that that will ease once she is not on such a high dose of medication. Pexion is a very pricey treatment ( which I wouldn’t mind paying for if it actually worked) with no benefits at all!

    • I understand that Pexion has no weaning off period. I put mine back on epiphen for a few weeks then stopped the pexion. I think it says you can do this on their website.

    • I know i wish i came across this thread before it was too late for my baby girl :( We have received her ashes today so it has been a very emotional day for all of us. I am still yet to write a long letter to my Vet about my disgust and disappointment. I have a bad feeling that Vets are describing this new medication Pexion because they are getting huge commission and they are treating our dogs as test animals to see how they react to this medication. As this is still being a fairly new medication it has not been thoroughly studied, hence none knows if this medication actually has any benefits for our dogs. I would advise everyone to stick to what works or if nothing seem to work to stick with Pheno so Epiphen or something similar as even if these medications have a side effect (which could damage liver but doesn’t always damage your pet`s liver ) it will control both idiopathic seizure as well as cluster seizure. I believe so far Pexion has not helped any dog to actually be seizure free and 80% of forums i read all reports that Pexion works great for the first few months than suddenly our beloved pet`s starts to suffer from not one but multiple seizures aka cluster seizure which is even more dangerous than a grand mal seizure.
      I really hope my little Angel can help to save other dog`s life from this nasty medication that should have never reached the shops or shall i say the vet`s shelves. Please share this post where you can to spread the world about this medication that Vet`s seem to describe for every epileptic dog :( Let`s not let Vet`s treat our dogs as test animals.
      P.S. I have read a post online that claims that putting a packet of ice on the back of your dog whilst she or he is having a fit helps to get them out quicker and make quicker recovery. It seemed to work a lot of people who have epileptic dog. Also giving them a spoon of ice cream seem to help their blood sugar level back on track. I will try to find the link and copy it in here for you guys.I hope your dog`s get better and will live a long healthy life.

  16. I know i wish i came across this thread before it was too late for my baby girl :( We have received her ashes today so it has been a very emotional day for all of us. I am still yet to write a long letter to my Vet about my disgust and disappointment. I have a bad feeling that Vets are describing this new medication Pexion because they are getting huge commission and they are treating our dogs as test animals to see how they react to this medication. As this is still being a fairly new medication it has not been thoroughly studied, hence none knows if this medication actually has any benefits for our dogs. I would advise everyone to stick to what works or if nothing seem to work to stick with Pheno so Epiphen or something similar as even if these medications have a side effect (which could damage liver but doesn’t always damage your pet`s liver ) it will control both idiopathic seizure as well as cluster seizure. I believe so far Pexion has not helped any dog to actually be seizure free and 80% of forums i read all reports that Pexion works great for the first few months than suddenly our beloved pet`s starts to suffer from not one but multiple seizures aka cluster seizure which is even more dangerous than a grand mal seizure.
    I really hope my little Angel can help to save other dog`s life from this nasty medication that should have never reached the shops or shall i say the vet`s shelves. Please share this post where you can to spread the world about this medication that Vet`s seem to describe for every epileptic dog :( Let`s not let Vet`s treat our dogs as test animals.
    P.S. I have read a post online that claims that putting a packet of ice on the back of your dog whilst she or he is having a fit helps to get them out quicker and make quicker recovery. It seemed to work a lot of people who have epileptic dog. Also giving them a spoon of ice cream seem to help their blood sugar level back on track. I will try to find the link and copy it in here for you guys.I hope your dog`s get better and will live a long healthy life.

  17. My 3 and a quarter year old lab has been on Pexion since a cluster of fits in May – he’d previously had single episodes each 6 months. The vet said that this cluster – of 3 inside an hour – meant that he had to be medicated and Pexion wouldn’t lead to drowsiness.

    Dizzy died 2 nights ago. He had a continuous, almost hour-long seizure, followed by sustained heavy breathing and staring ahead. I have no idea whether Pexion helped or not, but really? 3 years old?! Devastating. I don’t think my kids will ever understand cos I sure as hell don’t.

    • Hi George,

      I am so sorry to read our dog Dizzy passed away at such a young age. My princess was only 5 as well when she passed away last month due to a very similar seizure as your situation. Unfortunately there is not much that can explain what happened but it is scary that everyone`s dog seem to be getting cluster of seizures and longer fits on Pexion than on any other drugs. My dog was fine on Epiphen but the vet wanted to change to Pexion and 6 months later my dog is no longer with us. It still breaks my heart and in my opinion which i know it doesn’t really matter. Pexion has contributed to both of our dog`s such a short life :(
      I am sorry again for your loss … It will get easier…

      • Familiar story, my dog Izzy was also a casualty of this drug, She was put to sleep on 2nd Sept 2013 and I still talk about her every day, the whole family misses her too and it is over a year on. So sorry for your loss – more vets should read these postings before giving Pexion. It seems when other drugs have been used the pexion seems not to work. More research should be carried out on it as it can also have disasterous effects when stopped as instructed if no other medication is in place prior to withdrawing pexion.

  18. Hi My dog Beau…. A Springer Spaniel was diagnosed with idiopathic epilepsy about 12 months ago….. he was having a seizure about once a week He was prescribed Pexion at the lowest dose and this then reduced the fits to once a month this continued until the increase in frequency returned… To cut a long story short we find ourselves in a viscous circle, where beau builds a tolerance to a higher dose the fits return as we do to the vet and so does the same with the vet charges… Don,t get me wrong I would sell my soul for my dog, but I have found more words of advice on this site in the last half hour than I have when my vet buries his head in his dosage book… I can tell when Beau is going to Fit.. Some classic signs are Extremely clingy….I.E constant pawing and wanting to be on my knee etc… It also seems to happen between the hours of 2-6am when all is quiet… I would say that over exertion is a trigger as is any stress, i would like to thank people for taking the time to put experiences on here, I will be trying the high protein diet,vitamin supplements and rectal Diazapam -prior to any seizure and will report…. if he suffers another cluster I will be taking some of these comments to the vets and demand that pexion is stopped as the story from Eva is scarily like mine!!!

  19. My twelve and a half year old Cooker Spaniel started fitting about two years ago and the fits continued in frequency and duration for the fist year without any treatment.
    The vet then suggested Pexion and it had seemed to stop the fitting until the last 2 months where Georgie has again begun to fit in clusters. His fits are long and he is always doubly incontinent.

    As to the drug side effects, he walks around as though he is drunk (it really is quite distressing) and has a voracious appetite eating anything he can find, paper, tissues plants in the garden, nothing is safe. I know he is an old dog, but I love him and really don’t know what to do for the best

  20. I have two dogs both on Pexion. Mable who is 9 years old and has been on Pexion 400mgs x 2 twice a day (12hrs) apart since December, 2013 and was doing well but now has to have Keppra added as she is fitting more regular. Fizz who is 5 years old has been on Pexion with Keppra same dose as Mable is doing great after having numerous fits which she was admitted to the emergency vets in August, 2014, she is also on Epiphen.

  21. I have read so many reports of dogs having problems with this drug and I see
    a petition has been started up to get Boehringer to make further studies.

    There is a report available online :

    The pharmacological response to imepitoin (this is Pexion) may vary and
    efficacy may not be complete. Nevertheless Imepitoin is considered to be a
    suitable treatment option in some dogs because of its safety profile (see
    Section 5.1). On treatment, some dogs will be free of seizures, in other
    dogs a reduction of the number of seizures will be observed, whilst others
    may be non-responders. In non-responders, an increase in seizure frequency
    may be observed. Should seizures not be adequately controlled, further
    diagnostic measures and other antiepileptic treatment should be considered.
    The benefit/risk assessment for the individual dog should take into account
    the details in the product literature.3
    The efficacy of the veterinary medicinal product in dogs with status
    epilepticus and cluster seizures has not been investigated. Therefore,
    imepitoin should not be used as primary treatment in dogs with cluster
    seizures and status epilepticus. Transition to other types of antiepileptic
    therapy should be done gradually and with appropriate clinical supervision.

  22. My 8yr. old Yorkshire Terrier has been on Pexion for idiopathic epilepsy The dosage has been increased over time from 100mgs bd to 200mgs bd It has gone up again this week to 250mgs bd because his fits have not decreased from an average of 4/6 per month. If this does not reduce the number of fits my vet is considering adding Potassium Bromide. Pexion does not appear to be reducing the number of fits,which is concerning me because of the prospect of having to get him to swallow more tablets.

  23. My irish setter has been trialling Pexion along with Epiphen and still continues to fit. I was recommended to trial Pexion as the long term use of Epiphen and Libromide has a detrimental effect on the liver.

    My dogs seizure patterns is unchanged.

  24. Hi,
    Can anyone tell me the name of the vitamin that is supposed to protect a dogs liver when taking Epiphen that you can buy on pet meds?
    Many thanks

    • It’s not a vitamin it’s a supplement called milk thistle, in a tincture is easier to administer as well.

    • Please please all of you who have dogs with epilepsy, try a RAW diet for your dogs, which does mean a RAW lamb or beef bone every day or every other day. Raw meat, raw veg. Raw chicken wings. Its so easy to do, none of this horrid dried food full of chemicals. |Dogs used to live in the wild eating raw food, so why are we changing all of their natural diet. Most dogs develop peridontal disease if they are never given bones to grind their teeth on. This in itself can lead to heart problems, skin infections, seizures etc. I have read so many books on how to feed a dog a raw diet.
      It was too late for my old collie who had seizures for a year before she was put to sleep. It seems to me that pexion only works for a year if at all for many dogs. If I had had my time again, I would never have used such a new drug. I have heard over a thousand bad reports about this drug and there are clearly very few benefits that I can see.

      All the best to you all.


      • Dear Elizabeth
        I came to the same conclusion for my epileptic collie and fed a raw diet, unfirtunately after being on pexion for 2 months she was put to skeep as the fits took over (she over 30 seizures a day the last 2 weekends) before my said to let her go. There are sone really could groups on facebook offering excellent advice and support about starting raw feeding for animals.

  25. Hi
    It has been upsetting to read the more recent posts regarding the deaths of some contributors’ dogs.
    However, for balance, I have felt compelled to sign up and contribute to the debate.
    I have had a 3 1/2 year old male Giant Schnauzer on Pexion now for just over 12 months.
    His seizures were initially around 6 weeks apart, normally two or three over a 2 hour period. His recovery was always rapid.
    When his seizures started recurring every 4 weeks and with increased intensity, he was put on Pexion, initially 800mg every 12 hours. This worked with remarkable success for 6 months, during which he didn’t have a single episode.
    We then had an awful breakthrough cluster with him seizing every couple of hours through the night hours, for which we also had to administer rectal diazepam, I recall it being 40mg. Again, the result was the seizures stopped and he was back to his normal self again the next day.
    Pexion was increased to 1200mg every 12 hours.
    Again, we had a period of relative bliss with no seizures for a couple of months.
    Inevitably, he again suffered a prolonged episode, lasting over 48 hours. Diazepam was again used, but the duration of the episode was worrying.
    Five weeks on, he had yet another prolonged episode. However, now on 1400mg of Pexion twice a day, each seizure was significantly less intense than the previous time.
    I feel we have have gone through a process of finding the right dose of Pexion for him and his weight, as I do suspect we would have had far more episodes were it not for the Pexion.
    Touch wood, we have had no further seizure for just over a month now. Our Vet has advised me maintain the current dose, but has warned we will inevitably still get breakthroughs occasionally.
    He seems to have had none of the side effects others have been unfortunate to witness and catalogue and for now, I’m maintaining the faith with this drug; he is alert, active, a good weight, though his propensity to drink like a fish has caused the occasional Lake Windermere sized accident in the house.
    It has been no fun coping with and clearing up after a 55kg epileptic dog, but Pexion seems on balance to have eventually brought the condition under control, atleast in his case.

    • Post script to add: He has been raw fed from being weaned. We have supplemented his medication with Valerian and Skull cap from Dorwest.

    • It’s really good to see another positive comment on here. My 25kg labradoodle has been on Pexion for 18 months now. He started on 400mg twice a day and after a period of seizures in January we upped it to 600mg morning and 400mg in the evening. He had a few seizures in February and March so we upped it to 600mg twice a day. He has only had one seizure since this which was back in June. He has no side effects and is not overly hungry or thirsty.

      I have also started feeding him a raw diet . I have no idea whether this helps, but I have my happy, healthy dog back. Long may it last.

    • I totally agree it is nice to read something positive about Pexion. My border collie who will be 3 in February was diagnosed in March last year. It has been trial and error getting the dose right but he has been 6 weeks so far since his last one which was a 12 1/2 week gap from the previous one so I was really pleased with this. It is awful living with a dog with this condition as especially during the night any unusual sounds has me awake and he makes plenty of them during the night!!! He’s not a very good sleeper very restless. But I would never give up on him. He has other problems, he is deaf and has hip dysplasia as well.
      I am convinced food plays a huge part in this condition. I only feed him natural kibble from the Natural Dog Food Company. His only treat is one Dentastix a day and I read a few months ago a vet who recommended Omega 3 & 6 to be beneficial for dogs with epilepsy. I buy these from Treasure Your Health, they are on the net and really quick at delivery. They are in fact Omega 3,6 & 9. So whether it is the Omega working with the Pexion that has helped him, I am not sure but I think it has played a big part. All the people who have not had any luck with Pexion do need to look seriously at what they are feeding their dogs.

      • Hello janet.

        food does play a massive part you are quite right. We are what we eat and the same applies to dogs. Feeding raw is easy once you get used to it. Having lost my female collie at 13 to epilepsy, I now feed my one yr old Collie RAW. He is happy , healthy and the vets say What a wonderful coat he has” I give him Brewers Yeast tablets, 4 a day as Jock is 17 kg. That avoids using the chemical Frontline or Advocate. Fleas do not like the smell of garlic and B vitamins in the yeast. I then give him 2/3 raw meat ( beef, chicken, lamb, venison, rabbit, turkey) raw mashed veg (any veg) teaspoon of baked beans (organic) Natural yoghurt, 1 teas, Cottage Cheese 1 teas. Porridge oats, (soaked for few hours) 2 tabl brown cooked rice. Teas organic peanut butter. He also has a Raw meaty bone every other day to keep his teeth clean, white and avoid periodontal disease which in itself can cause fits.

        it sounds complicated, but its dead easy and dogs love it. No more kibble of any sort, not even the so called” Natural” Treats are raw carrots or banana or apple.

        Dogs also do not need parvo injections every year. This only lines the pockets of the vets and can cause complications.

        All the best,


  26. It is also correct to say that a home-cooked diet is helping a ton of dogs,
    or a liver cleansing diet. And, believe it or not, many prescription diets
    DO help. But it does not mean that every dog will suit the same diet.

    There is no one-size-fits-all when it comes to feeding dogs – or people, for
    that matter. A raw diet is not recommended for dogs with liver disease and
    before my dog was diagnosed with liver disease he simply would not touch
    raw food, neither would his mummy. So he knew better than I did what he

    Also, my old dog, Sam, came to us as a rescue and, same as all my dogs
    back then (1998) he was started on a raw diet. Within months it was obvious
    that this diet simply did not suit him, he was awfully poorly, vomiting
    constantly, losing weight even though he loved his food. Eventually he was
    put on what was then Walthams Capelin & Tapioca kibble, now it is Royal
    Canin Sensitivity Control. Sam thrived on that and lived to be a very old
    boy of somewhere between 15 and 17 years old.

    My friend has always fed her dogs kibble and her dogs have always ended up
    being around 16 years old when they die, unlike mine who never used to live
    past 13½ years old, except my first epi, who lived on a homecooked
    diet and she lived until she was 14½ and died of throat and liver cancer.
    My 15-yr-old who came to us last January, was fed kibble or canned for
    her first 14 years, she was terribly neglected, obese, scruffy, smelly,
    diagnosed with Cushings the week after we adopted her. But she has lived
    all these years on what I would not feed my dogs.

    So I would never say that one diet or another whether raw, kibble, canned,
    homecooked is best. And I get really angry with anyone who says that one
    diet and one diet only is best.

    I fed raw for 12 years and my vet visits were not fewer, my dogs’ health was
    o better than when I homecooked and now homecook again.

  27. My dog who is 4 has been on this medication for 2 months now and henis on 400mg twice a day and still fitting on them. His last fitvwas 1e days ago and now today at 5.45am he had a small fit lasting 30secs and then again at 8.30am and that lasted 30 secs. We spoke to our vet and going to tp company who make these tabs if we can give him one an half. We have been told to see a neruo surgeon but its expensive. Any adbise would be helpfull as we are so concerned and we have a 8 yr ols female staff whonwe always keep apart.

    • Janice, my dog didn’t stop fitting on Pexion, he is now on PB and doing so well, I didnt like the drug at all, another friend changed her dog as well onto PB and his fits are non existent as well

    • Pheno barb, or epiphen. I saw a neuro guy in Bristol, we had MRI and a full work up but found nothing. He was the European specialist in Epilepsy and he said his first choice of drug is PB interestingly enough even though its an old drug. My boy was having a series of fites every few weeks and it was dreadfuly distressing for him, his post ictal stage would last for hours, touch wood we have been fit free for over 6 months now

      • Phenobarb is probably the most effective and the cheapest anti-epileptic drug on the market. I was using it back in the 90s for one of my epis and when my current epi (I’ve had a few!) started to have fits I had no hesitation in putting her on pheno. You just need to make sure that the liver enzymes are checked regularly – my dogs’ internal medicine specialist in Cheshire thinks it better to have bile acid stimulation tests as that is a better indicator of liver function. You can help counter any damage to the liver by giving milk thistle.

      • Yeah I googled it and spoke to my husband andbhe spoke with vet today and vets checkin if we can put him on one an half pills even though he all ready on 400mg twice a day. Our dog is havin two its a month. Before he was on meds his fits were bad 5 fits a day he was having, because of the toxic levels in his body, he was poisoned in a field were we walk our dogs and out the blue he started havin fits bad ones. Vet done blood tests and his levels was 1157 were a dogs level should be 120. But hisnliver was damaged to wat he had eaten producing toxins intonhis body causin him to fit. Thats was 3mths ago all this started and he now on meds and still fitting, I know on these tabs he will still have the occasional fit but two in a space of hour an a half. Me an my husband are so worried he is only a baby 4yrs old just turned in may.we dont want to loose him , he like our child, we love this dog and seein him suffer likenthis in killing us but thank you for your advise muchly appercaited.

  28. its a horrid thing for any dog to have, with Pexion you can up the dose, but I would seriously ask you vet to consider swapping you onto PB

    • There are responders and non responders to Pexion,the drug literature states that it’s not recommended for cluster fits and can worsen them. You can increase dose but PB was always effective in fit control. If liver is Ok, Pexion does not offer any advantage! Try liver protection measures as seen in the site before. Talk to your vet about combo drugs. Dog epilepsy is horrible!

  29. M dog Daisy started taking Epiphen 10 weeks ago. She is slowly being weaned off of Pexion, her Pexion is decreased by a quarter each month, finger crossed she has been fit free for 10 weeks since starting the Epiphen! next week her Pexion is being decreased for the last time and she will no longer be taking Pexion in a months time. I am so happy going 10 weeks with no fits where as before she was fitting twice a week and had an awful episode of cluster fits, which nearly killed her and never happened before starting Pexion. Janice I do hope that you find the right tablets for your furbaby.

  30. Our little fur baby Cassie started having seizures end of August, and then 3 weeks later had two seizures both between 2-4.30am and went to the vets, nothing wrong with blood but put on 400mg Pexion (she is a chihuahua/staffy cross). next seizure was 11 days later, then 3 1/2 weeks later, had 2 seizures within 36 hours. Next seizure was 12 days later and most recent this morning, 12 days later (8th seizure in 12 weeks) . She had just extracted herself from my side under the covers, went over to the edge of the bed to see ‘dad’ I recognised a certain shake of the bed turned over and her head was erect and mouth slightly open (like when you look up and turn head slightly, mouth slightly open and it locks). They seem to last about 15 seconds, and she becomes incontinent (no1) and once recovers, goes downstairs and does a no2. She bruised her eye prior to the first seizure (which may be the cause and it is still a little bulgy and red, and her vision does seem impaired. I have not noticed any changes in her behaviour, but close patterns of seizures would concern me and am keeping notes of when they happen. Reading these posts, do have concerns, that the Pexion that will increase them. This knocks the stuffing out of me when they occur. As she sleeps with me I am conscious of certain movements and pressure when she lays on a certain side which over time may be leading to the seizures and sometimes wake up to check if responsive, mostly OK. . We rehomed her Jan 10 so do not exactly know her history or true age. She has always been my shadow and follows me around the house, so no change there, still a little dynamo. Just find it upsetting and makes me cry just writing this.

  31. my boder collie is 3 years old and js on pexion and a half twice a day.the vet said she would be on them for the rest of her life,is this right

    • If your BC has been diagnosed as having idiopathic epilepsy then yes, she will be on medication for the rest of ehr life. Not necessarily Pexion, if she doesn’t do ell on it, but expect her to be on medicaiton for the rest of her life. It is a life-changer, not just for the dog but for the family, too.

  32. mijn hond krijgt ni Pexion 100 mg en 2 tabletten per dag. Die mogen we volgend de dierenarts tegelijk geven.
    In de bijsluiter staat verdelen over 2 momenten met tussentijd van 10 uur??
    Ik geef onze hond nu om 17.30 uur 2 tabletten van 100 mg en vraag me af wat het beste is??
    Kan iemand advies hierin geven??

  33. The vet prescribed Pexion Friday 5 December 2014. Bailey has been on it since that day. No seizures as yet and no side effects either. I am hopeful, the only downside is the cost as insurance will not pay. At least he is seizure free at the moment.

    • Dear Dianne
      Check the price your vet is charging you, and how much they charge to write a prescription. Then go online at and see if it’s cheaper to buy that way. Pet drugs online are usually cheaper, they don’t issue prescription meds without your vets prescription and delivery is free over £20 I think. Vets don’t always let you know that you are able to source your own medication, especially when insurance doesn’t cover pre-existing conditions.
      Hope this is helpful. Good luck.

    • Hello Diane.

      Shani’s epilepsy isn’t covered by her insurance and so I shopped around to see what the prices were at the various online pharmacies. You can get a precription from your vet – he will charge but hopefully not too much, I pay £12 for Shani’s. But I found that one month’s supply of meds from my vet was almost the same as three months’ supply bought from a chemist online. I get the prescriptions (Shani is on 3 AEDs), send them to the pharamcy, they phone me for payment and I get the drug back and all that takes less than seven days. That is up to the far north of Scottland from a pharmacy down in Leicestershire.

  34. My border collie is 4 yrs old and has epilepsy one per week for a year. She is on Pb and Potassium Bromide. Her seizures are once in a week and lasts about 1 minute. Last week we were introduced to Pexion by our vet in an attempt to reduce the frequency of seizures; and we started on Monday at 200 mg twice a day. No Pb or Potassium Bromide was given. Her first seizure started on the first day. Today the second day she got another seizure followed by a third 15 hours later. I am worried she will get into a cluster of seizures. Can you advise what I should do?

    • Hi Gregory,

      Have you read the previous comments about this medication? It seems like this medication only work for 30 % of the pets and the rest 70% actually end up having more seizures and cluster or seizures and worst case is they did. I myself was in the unlucky group my dog was on Pheno B. For 2 years with no major problems but it was a struggle to take blood from her so it was more convenient for her vet to put her on pexion which was great for 2 months as she had no seizures but when she started having her first fit again she just couldn’t stop and had over 12 seizures in 6 hours and unfortunately when I took her to the emergency clinic they had to induce coma for her to check why the seizure don’t stop and by the time her lab came back she was gone. Her heart has stopped :( she was my everything and it was a terrible mistake to put her on Pexion even the emergency vet said Pelion is not fully approved yet and it doesn’t work on cluster seizures. So I would recommend you to go back to your vet and take your dog off of Pexion and put him back on Pheno also I would check what food he is eating because often seizures are caused due to food allergy

    • Gregory

      PLEASE get your dog to a vet urgently – one who understands anti epileptic medication. You must NEVER just stop phenobarbitone – it could kill your dog. If you do want to stop PB it must be done very gradually (months) with a vets supervision and another drug at optimum levels in place which takes time. Kbr should be continued if you are using Pexion in place of Pb. PLEASE PLEASE talk to a vet NOW!

      • Couldn’t agree more, no vet should ever stop medication for epilepsy. And why don’t more vets read about pexion and look at sites like this for feedback. It is so sad the number of dogs lost so far, my Izzy was amongst the first . I lost my beloved girl in September 2013 we couldn’t stop the fits and also had to be sedated 2 saturdays running after having fits all day non-stop. My thoughts go out to everyone who is in this continuous struggle with epileptic pets.
        Amanda Kirkman

    • Sorry to hear you and your dog are having a rough time with this awful condition. Perhaps my comments may help you and others. My border collie is 3 and has been having seizures for just over a year roughly one every 10 days even when he first started Pexion. He weighs 18kgs and was started at 200mg twice a day. This was having no effect so my vet increased him to 400mg twice a day. Food is extremely important and a lot of people use the raw food diet but I have found food from The Natural Dog Food Company which has no additives. He only has one dentastix per day, no other treats. I also read the Omega 3 and 6 is beneficial and he has 3 of these a day. I found these from Treasure your Health which sell Omega 3,6 & 9. He is given his tablet in the morning dead on 8 am on an empty stomach and his breakfast at 8.30 am. He has his dinner at 6 pm and is given his second tablet at 8 pm. It is a tie making sure the tablet is given at exact times, but it works for him and me!!! The longest he has gone is 12 weeks which I was really pleased with and at the moment he is on 10 weeks since his last one. I think it is the Omega helping. I hope this helps you but you do need to talk to your vet urgently.

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